Motif ID: FOX{I1,J2}.p2

Z-value: 0.941


Transcription factors associated with FOX{I1,J2}.p2:

Gene SymbolEntrez IDGene Name
FOXI1 2299 forkhead box I1
FOXJ2 55810 forkhead box J2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXJ2chr12_+_81852410.775.4e-04Click!
FOXI1chr5_+_1695329000.049.0e-01Click!


Activity profile for motif FOX{I1,J2}.p2.

activity profile for motif FOX{I1,J2}.p2


Sorted Z-values histogram for motif FOX{I1,J2}.p2

Sorted Z-values for motif FOX{I1,J2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{I1,J2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_19870209 6.118 NM_018993
RIN2
Ras and Rab interactor 2
chr1_+_150480486 3.857 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr3_+_158787040 3.473 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr21_-_27512668 3.107 NM_001136016
APP
amyloid beta (A4) precursor protein
chr20_+_19915716 2.946 RIN2
Ras and Rab interactor 2
chr9_+_75766777 2.434 NM_000700
ANXA1
annexin A1
chr13_+_50070096 2.319 PHF11
PHD finger protein 11
chr9_-_88715024 2.194 NM_177937
GOLM1
golgi membrane protein 1
chr13_-_110802708 2.070 COL4A1
collagen, type IV, alpha 1
chr7_-_87849341 2.007 SRI
sorcin
chr2_-_190044330 1.919 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_-_149086884 1.829 TM4SF1
transmembrane 4 L six family member 1
chrX_+_135278912 1.761 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr6_+_121756744 1.737 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr11_+_114167168 1.577 NNMT
nicotinamide N-methyltransferase
chr13_+_111134933 1.555 COL4A2
collagen, type IV, alpha 2
chr3_+_62305395 1.554 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr1_+_84609941 1.530 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_69467210 1.509 CCND1
cyclin D1
chr11_+_114167197 1.489 NNMT
nicotinamide N-methyltransferase
chr9_+_75766794 1.462 ANXA1
annexin A1
chr1_-_153599523 1.458 NM_001024213
S100A13
S100 calcium binding protein A13
chr1_+_158979681 1.408 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr1_-_57045235 1.406 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_71561687 1.353 COL13A1
collagen, type XIII, alpha 1
chr3_+_135741576 1.343 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr10_-_90712510 1.305 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_111312522 1.273 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr21_-_27253197 1.259 APP
amyloid beta (A4) precursor protein
chr5_+_53751430 1.231 NM_006308
HSPB3
heat shock 27kDa protein 3
chr12_-_91576805 1.223 NM_001920
DCN
decorin
chr18_-_53303129 1.208 NM_001243226
TCF4
transcription factor 4
chr12_-_91576579 1.158 DCN
decorin
chr12_-_10021932 1.099 CLEC2B
C-type lectin domain family 2, member B
chr6_+_151646634 1.092 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_48614013 1.092 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr4_+_38869346 1.083 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr8_+_74903563 1.066 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr7_-_87849366 1.058 NM_003130
SRI
sorcin
chr5_-_54281345 1.048 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr6_-_112575766 1.038 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr6_-_112575880 1.036 LAMA4
laminin, alpha 4
chr13_-_33859835 1.023 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_+_96212167 1.015 ERAP2
endoplasmic reticulum aminopeptidase 2
chr11_-_104827421 1.000 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_+_171154387 0.999 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr5_-_94224601 0.975 MCTP1
multiple C2 domains, transmembrane 1
chr2_-_56151273 0.970 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr1_+_84630575 0.964 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr21_+_30517897 0.964 C21orf7
chromosome 21 open reading frame 7
chr2_+_201170603 0.961 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr12_-_15038724 0.961 NM_000900
NM_001190839
MGP

matrix Gla protein

chr10_+_71561643 0.960 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr18_-_53177999 0.959 NM_001243231
TCF4
transcription factor 4
chr15_+_25068793 0.950 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr10_-_126849066 0.945 NM_001329
CTBP2
C-terminal binding protein 2
chr10_+_124145584 0.941 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_170335948 0.934 NM_152384
BBS5
Bardet-Biedl syndrome 5
chr3_+_11267666 0.933 NM_001098211
HRH1
histamine receptor H1
chr1_-_173174611 0.922 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr22_-_43036606 0.907 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr8_+_79428335 0.898 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr6_+_29855349 0.894 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr5_+_34687663 0.892 NM_001145523
RAI14
retinoic acid induced 14
chr12_-_105627182 0.891 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr1_+_15764934 0.889 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr6_-_112575708 0.886 LAMA4
laminin, alpha 4
chr1_-_57045214 0.884 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_114343052 0.858 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_71502700 0.851 MAP1B
microtubule-associated protein 1B
chr7_-_150329285 0.849 GIMAP6
GTPase, IMAP family member 6
chr10_-_126849010 0.846 CTBP2
C-terminal binding protein 2
chr1_+_44064509 0.845 PTPRF
protein tyrosine phosphatase, receptor type, F
chr10_+_54074037 0.845 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr1_-_170043608 0.844 NM_001204514
NM_001204516
NM_014970
KIFAP3


kinesin-associated protein 3


chr4_-_186456580 0.831 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr12_+_119616594 0.828 NM_014365
HSPB8
heat shock 22kDa protein 8
chr1_-_77685076 0.823 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr11_-_17191287 0.819 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr8_-_23261675 0.819 NM_002318
LOXL2
lysyl oxidase-like 2
chr2_+_201473942 0.813 AOX1
aldehyde oxidase 1
chr16_+_8715473 0.794 NM_024109
METTL22
methyltransferase like 22
chr10_+_63808968 0.792 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_23261632 0.788 LOXL2
lysyl oxidase-like 2
chr19_+_1026271 0.762 NM_004368
NM_201277
CNN2

calponin 2

chr13_+_50069745 0.757 NM_001040443
PHF11
PHD finger protein 11
chr6_+_114178516 0.751 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr4_-_70826712 0.745 NM_001891
CSN2
casein beta
chr8_-_93111915 0.743 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_84630374 0.727 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_201170795 0.722 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr2_-_179672056 0.718 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr18_+_61554938 0.709 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr3_+_183892668 0.709 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr12_-_10022457 0.708 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr1_+_223900061 0.700 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr9_+_79115548 0.689 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr2_-_151344145 0.689 NM_005168
RND3
Rho family GTPase 3
chr5_-_111091947 0.679 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr17_-_46688362 0.671 NM_004502
HOXB7
homeobox B7
chr19_-_4400470 0.669 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr1_-_163172863 0.662 NM_003617
RGS5
regulator of G-protein signaling 5
chr4_+_146403955 0.658 NM_001003688
SMAD1
SMAD family member 1
chr3_+_183892662 0.656 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr19_+_50031232 0.655 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr17_-_48264039 0.647 COL1A1
collagen, type I, alpha 1
chr21_-_27543445 0.641 NM_001136131
APP
amyloid beta (A4) precursor protein
chr3_+_183892647 0.631 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr11_+_63304272 0.626 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr4_+_47487230 0.623 NM_020453
ATP10D
ATPase, class V, type 10D
chr4_+_89299874 0.620 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr9_+_124086842 0.616 GSN
gelsolin
chr9_-_14086901 0.610 NFIB
nuclear factor I/B
chr9_-_117880411 0.610 NM_002160
TNC
tenascin C
chr4_+_15704572 0.610 NM_004334
BST1
bone marrow stromal cell antigen 1
chr2_+_152214105 0.609 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_-_57045129 0.605 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_125695787 0.594 NM_001146319
GRAMD3
GRAM domain containing 3
chr7_+_76026819 0.593 NM_007155
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr14_+_62164339 0.591 NM_001243084
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr1_-_244006471 0.590 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr11_-_8739398 0.586 ST5
suppression of tumorigenicity 5
chr13_-_52980628 0.581 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr11_+_5710816 0.579 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr1_+_157963062 0.579 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr12_+_10365415 0.578 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr8_+_144640476 0.577 NM_024736
GSDMD
gasdermin D
chr6_+_153019029 0.577 NM_025107
MYCT1
myc target 1
chr20_+_9288446 0.576 NM_000933
PLCB4
phospholipase C, beta 4
chrX_-_10851808 0.576 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr18_-_21852189 0.568 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr9_+_132962871 0.559 NM_001128826
NCS1
neuronal calcium sensor 1
chr3_+_183892569 0.558 NM_001025205
NM_004068
AP2M1

adaptor-related protein complex 2, mu 1 subunit

chr15_+_25101697 0.557 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr4_-_16900028 0.557 LDB2
LIM domain binding 2
chr8_+_54764367 0.557 NM_170587
RGS20
regulator of G-protein signaling 20
chr21_-_43346780 0.552 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr6_-_128841432 0.550 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr4_+_89299980 0.547 HERC6
hect domain and RLD 6
chr1_-_110933683 0.545 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr4_-_102268626 0.543 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr8_-_93107442 0.543 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr1_+_150122415 0.537 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr4_-_16900256 0.530 LDB2
LIM domain binding 2
chr3_+_45067750 0.524 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr2_+_102953716 0.522 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr1_+_171060017 0.518 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr15_+_64680002 0.515 NM_016213
TRIP4
thyroid hormone receptor interactor 4
chr18_+_72922725 0.515 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr4_+_77953942 0.513 SEPT11
septin 11
chr8_-_13134028 0.513 DLC1
deleted in liver cancer 1
chr1_+_19969722 0.512 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr10_-_29754478 0.509 SVIL
supervillin
chr2_+_207406815 0.505 ADAM23
ADAM metallopeptidase domain 23
chr2_+_20646831 0.502 NM_004040
RHOB
ras homolog gene family, member B
chr8_-_17658385 0.499 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chrX_+_114827818 0.495 NM_001136025
NM_001172335
PLS3

plastin 3

chr5_+_140718353 0.489 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr19_-_52255099 0.489 NM_001193306
NM_002029
FPR1

formyl peptide receptor 1

chr4_-_102267952 0.489 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr4_-_16900348 0.486 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr22_-_36424397 0.478 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr12_-_102455763 0.476 CCDC53
coiled-coil domain containing 53
chr7_-_93519990 0.476 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr1_-_153599743 0.474 NM_001024212
S100A13
S100 calcium binding protein A13
chr2_-_188419185 0.471 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_-_227664330 0.471 IRS1
insulin receptor substrate 1
chr8_-_93107881 0.462 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr1_-_110933635 0.462 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr13_-_33780142 0.461 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr3_+_128968470 0.459 COPG
coatomer protein complex, subunit gamma
chr12_+_56915587 0.457 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr7_+_89783688 0.456 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr19_+_14491920 0.456 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr3_-_15382874 0.455 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr9_-_16727887 0.453 BNC2
basonuclin 2
chr3_-_114102488 0.450 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr18_+_22006611 0.449 IMPACT
Impact homolog (mouse)
chr12_+_78225068 0.449 NM_014903
NAV3
neuron navigator 3
chr6_-_134496833 0.443 SGK1
serum/glucocorticoid regulated kinase 1
chr5_+_140734767 0.441 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr4_+_90816002 0.439 NM_007351
MMRN1
multimerin 1
chr8_-_12973752 0.439 NM_001164271
DLC1
deleted in liver cancer 1
chr20_-_44538654 0.438 PLTP
phospholipid transfer protein
chr5_-_68616299 0.437 NM_176816
CCDC125
coiled-coil domain containing 125
chr1_+_84630014 0.437 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr19_-_4400357 0.436 NM_001199944
SH3GL1
SH3-domain GRB2-like 1
chr1_+_82266081 0.435 NM_012302
LPHN2
latrophilin 2
chr7_+_89783789 0.434 STEAP1
six transmembrane epithelial antigen of the prostate 1
chrX_+_80457302 0.434 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_-_21776158 0.434 NM_014332
SMPX
small muscle protein, X-linked
chr2_-_188312872 0.431 NM_005795
CALCRL
calcitonin receptor-like
chr1_+_101185195 0.428 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr2_-_133429069 0.428 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr3_+_35721115 0.426 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr7_-_95064213 0.426 NM_000305
NM_001018161
PON2

paraoxonase 2

chr8_-_108510094 0.421 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr20_+_9198036 0.421 NM_182797
PLCB4
phospholipase C, beta 4
chrX_-_6145887 0.421 NM_020742
NLGN4X
neuroligin 4, X-linked
chr12_-_102455793 0.420 NM_016053
CCDC53
coiled-coil domain containing 53

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
53.26 1.94e-06 GO:0005581 collagen
21.54 1.81e-05 GO:0044420 extracellular matrix part
10.07 2.88e-04 GO:0005578 proteinaceous extracellular matrix
8.34 9.95e-04 GO:0031012 extracellular matrix
117.14 7.76e-03 GO:0005587 collagen type IV
100.41 1.09e-02 GO:0030935 sheet-forming collagen
2.98 2.08e-02 GO:0005576 extracellular region
3.81 2.51e-02 GO:0044421 extracellular region part
18.20 3.81e-02 GO:0005604 basement membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
25.86 6.10e-05 GO:0005201 extracellular matrix structural constituent